Introduction to a Resources Special Issue on Criticality of the Rare Earth Elements: Current and Future Sources and Recycling

The rare earth elements (REE) are vital to modern technologies and society and are amongst the most important of the critical elements. This special issue of Resources examines a number of facets of these critical elements, current and future sources of the REE, the mineralogy of the REE, and the economics of the REE sector. These papers not only provide insights into a wide variety of aspects of the REE, but also highlight the number of different areas of research that need to be undertaken to ensure sustainable and secure supplies of these critical metals into the future

Numerical Simulation Based Targeting of the Magushan Skarn Cu-Mo Deposit, Middle-Lower Yangtze Metallogenic Belt, China

The Magushan Cu–Mo deposit is a skarn deposit within the Nanling–Xuancheng mining district of the Middle-Lower Yangtze River Metallogenic Belt (MLYRMB), China. This study presents the results of a new numerical simulation that models the ore-forming processes that generated the Magushan deposit and enables the identification of unexplored areas that have significant exploration potential under areas covered by thick sedimentary sequences that cannot be easily explored using traditional methods. This study outlines the practical value of numerical simulation in determining the processes that operate during mineral deposit formation and how this knowledge can be used to enhance exploration targeting in areas of known mineralization. Our simulation also links multiple subdisciplines such as heat transfer, pressure, fluid flow, chemical reactions, and material migration. Our simulation allows the modeling of the formation and distribution of garnet, a gangue mineral commonly found within skarn deposits (including within the Magushan deposit). The modeled distribution of garnet matches the distribution of known mineralization as well as delineating areas that may well contain high garnet abundances within and around a concealed intrusion, indicating this area should be considered a prospective target during future mineral exploration. Overall, our study indicates that this type of numerical simulation-based approach to prospectivity modeling is both effective and economical and should be considered an additional tool for future mineral exploration to reduce exploration risks when targeting mineralization in areas with thick and unprospective sedimentary cover sequences

Future Availability of Non-renewable Metal Resources and the Influence of Environmental, Social, and Governance Conflicts on Metal Production

Metal mining provides the elements required for the provision of energy, communication, transport and more. The increasing uptake of green technology, such as electric vehicles and renewable energy, will also further increase metal demand. However, the production lifespan of an average mine is far shorter than the timescales of mineral deposit formation, suggesting that metal mining is unsustainable on human timescales. In addition, some research suggests that known primary metal supplies will be exhausted within about 50 years. Here we present an analysis of global metal reserves that suggests that primary metal supplies will not run out on this timescale. Instead, we find that global reserves for most metals have not significantly decreased relative to production over time. This is the result of the replenishment of exhausted reserves by the further delineation of known orebodies as mineral exploration progresses. We suggest that environmental, social, and governance factors are likely to be the main source of risk in metal and mineral supply over the coming decades, more so than direct reserve depletion. This could potentially lead to increases in resource conflict and decreases in the conversion of resources to reserves and production

Structural basis for complement factor H-linked age-related macular degeneration

This is the final version of the article. Available from the publisher via the DOI in this record.Nearly 50 million people worldwide suffer from age-related macular degeneration (AMD), which causes severe loss of central vision. A single-nucleotide polymorphism in the gene for the complement regulator factor H (FH), which causes a Tyr-to-His substitution at position 402, is linked to approximately 50% of attributable risks for AMD. We present the crystal structure of the region of FH containing the polymorphic amino acid His402 in complex with an analogue of the glycosaminoglycans (GAGs) that localize the complement regulator on the cell surface. The structure demonstrates direct coordination of ligand by the disease-associated polymorphic residue, providing a molecular explanation of the genetic observation. This glycan-binding site occupies the center of an extended interaction groove on the regulator's surface, implying multivalent binding of sulfated GAGs. This finding is confirmed by structure-based site-directed mutagenesis, nuclear magnetic resonance-monitored binding experiments performed for both H402 and Y402 variants with this and another model GAG, and analysis of an extended GAG-FH complex.B. Prosser is funded by the Wellcome Trust Structural Biology Training Program (075415/Z/04/Z). S. Johnson and P. Roversi were funded by grants to S.M. Lea from the Medical Research Council (MRC) of the United Kingdom (grants G0400389 and G0400775). D. Uhrin and P.N. Barlow were funded by the Wellcome Trust (078780/ Z/05/Z). S.J. Clark was funded by an MRC Doctoral Training Account (G78/7925), and R.B. Sim and A.J. Day were funded by MRC core funding to the MRC Immunochemistry Unit

Numerical Modeling of Mineralizing Processes During the Formation of the Yangzhuang Kiruna-Type Iron Deposit, Middle and Lower Yangtze River Metallogenic Belt, China: Implications for the Genesis and Longevity of Kiruna-Type Iron Oxide-Apatite Systems

The Yangzhuang iron deposit is a Kiruna-type iron oxide-apatite (IOA) deposit within the Ningwu mining district of the Middle and Lower Yangtze River Metallogenic Belt (MLYRMB), China. This study applies a numerical modeling approach to identify the key processes associated with the formation of the deposit that cannot be easily identified using traditional analytical approaches, including the duration of the mineralizing process and the genesis of iron orebodies within intrusions associated with the deposit. This approach highlights the practical value of numerical modeling in quantitatively analyzing mineralizing processes during the formation of mineral deposits and assesses how these methods can be used in future geological research. Our numerical model links heat transfer, pressure, fluid flow, chemical reactions, and the movement of ore-forming material. Results show that temperature anomaly and structure (occurrence of the contact of intrusion and the Triassic Xujiashan group) are two key factors controlling the formation of the Yangzhuang deposit. This modeling also indicates that the formation of the Yangzhuang deposit only took some 8000 years, a reaction that is likely to be controlled by temperature and diffusion rates within the system. The dynamic changes of temperature and the distribution of mineralization also indicate that the orebodies located inside the intrusions most likely formed after magma ascent rather than representing blocks of existing mineralization that descended into the magma as a result of stoping or other similar processes. All these data form the basis for future research into the forming processes of Kiruna-type IOA systems as well as magmatic–hydrothermal systems more broadly, including providing useful insights for future exploration for these systems. The simulation approach used in this study has several limitations, such as oversimplified chemical reactions, uncertainty of pre-metallogenic conditions and limitation of 2D model. Future development into both theories and methods will definitely improve the practical significance of numerical simulation of ore-forming processes and provide quantitative results for more geological issues

Arc‐Type Magmatism Due to Continental‐Edge Plowing Through Ancient Subduction‐Enriched Mantle

The puzzling... (See article for full abstract)

3D Numerical Simulation-Based Targeting of Skarn Type Mineralization within the Xuancheng-Magushan Orefield, Middle-Lower Yangtze Metallogenic Belt, China

Recent exploration has identified a series of Cu-Mo skarn deposits within the Xuancheng-Magushan orefield. The orefield forms part of the Nanling-Xuancheng mining district, which is located within the Middle-Lower Yangtze River Metallogenic Belt (MLYRMB) of central-eastern China. However, this area contains thick and widespread unprospective sedimentary cover sequences that have impeded traditional approaches to mineral exploration. This study presents the results of 3D numerical simulation modeling that identifies possible mineral exploration targets within the entire Xuancheng-Magushan orefield. This modeling enables the identification of unexplored areas with significant exploration potential that are covered by thick sedimentary sequences that cannot be easily explored using traditional exploration approaches. This study outlines the practical value of 3D numerical simulation-based targeting in areas with thick sedimentary cover sequences and uses the Flac(3D) software package to couple processes involved in ore formation such as stress, pressure, and heat transfer. Here, we use volumetric strain increments calculated during numerical modeling as the thermodynamic representation of the generation of space during prograde skarn formation, with this space filed by sulfides either penecontemporaneously or soon after magmatism. This process occurred during retrograde hydrothermal ore formation and the genesis of the skarn-type mineralization in this area. The results of the volumetric strain increment calculated during this numerical modeling study matches the distribution of known mineralization as well as delineating eight potential targets that have not yet been explored but represent areas of significant exploration potential within the Xuancheng-Magushan orefield, indicating these targets should be considered prospective for future mineral exploration. One of these targets was also identified during our previous Comsol-based numerical modeling of the formation of the Magushan Cu-Mo skarn deposit. The fact that this area has been identified as prospective using two different numerical modeling methods indicates that this area should be prioritized for future exploration and also validates the numerical modeling approaches used here and in our previous research that more specifically focused on the Magushan skarn deposit. Overall, our study indicates that prospectivity modeling using 3D numerical simulation-based approaches can be both effective and economical and should be considered an additional tool for future mineral exploration to reduce exploration risks when targeting mineralization in areas with thick and unprospective sedimentary cover sequences

Interactive Computer Technology for Planning and Policy Modeling

This paper speculates on the potential impacts of our increasing access to and use of computer technology and communication, especially with respect to planning and policy making. The focus of the discussion is on the interaction between the users of this expanding technology and the technology itself. Those involved in its development, whether it be the hardware or software of this technology, are in a position to make substantial contributions toward a more effective use of the models and their data bases by planners and policy analysts. Specific features of the technology and of environmental planning and policy-making processes are examined to identify where and how interactive computer-based models and associated hardware can best serve individuals, their organizations or institutions. Finally, the necessary conditions for the successful implementation of such tools and methods are identified

Global patient outcomes after elective surgery: prospective cohort study in 27 low-, middle- and high-income countries.

BACKGROUND: As global initiatives increase patient access to surgical treatments, there remains a need to understand the adverse effects of surgery and define appropriate levels of perioperative care. METHODS: We designed a prospective international 7-day cohort study of outcomes following elective adult inpatient surgery in 27 countries. The primary outcome was in-hospital complications. Secondary outcomes were death following a complication (failure to rescue) and death in hospital. Process measures were admission to critical care immediately after surgery or to treat a complication and duration of hospital stay. A single definition of critical care was used for all countries. RESULTS: A total of 474 hospitals in 19 high-, 7 middle- and 1 low-income country were included in the primary analysis. Data included 44 814 patients with a median hospital stay of 4 (range 2-7) days. A total of 7508 patients (16.8%) developed one or more postoperative complication and 207 died (0.5%). The overall mortality among patients who developed complications was 2.8%. Mortality following complications ranged from 2.4% for pulmonary embolism to 43.9% for cardiac arrest. A total of 4360 (9.7%) patients were admitted to a critical care unit as routine immediately after surgery, of whom 2198 (50.4%) developed a complication, with 105 (2.4%) deaths. A total of 1233 patients (16.4%) were admitted to a critical care unit to treat complications, with 119 (9.7%) deaths. Despite lower baseline risk, outcomes were similar in low- and middle-income compared with high-income countries. CONCLUSIONS: Poor patient outcomes are common after inpatient surgery. Global initiatives to increase access to surgical treatments should also address the need for safe perioperative care. STUDY REGISTRATION: ISRCTN5181700